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10.3389/fnut.2025.1520695 102 ZdrojkowskiŁ.JasińskiT.Ferreira-DiasG.PawlińskiB.DominoM
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Increased Gb3 expression and lipid accumulation in GLA-KO human iPSC kidney organoids Next, to determine the accumulation of Gb3, a main pathological mechanism in human Fabry disease 6,7 , confocal microscopy was performed, which revealed extensive accumulation of Gb3 in podocytes and tubular cells in GLA-mutant human iPSC kidney organoids (Fig
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