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(basic) Methylation cycle (15-20) methionine MAT S-adenosyl- Methionine (SAMe) MTs MTR, MTRR S-adenosyl- Homocysteine (SAH) homocysteine ACHY (basic) Methylation cycle with BHMT pathway added (15-20) [Note that BHMT is found only in liver and kidney cells(22).] methionine MAT S-adenosyl- methionine DMG MTs MTR, MTRR BHMT TMG (betaine) S-adenosyl- homocysteine homocysteine AHCY (complete) Methylation cycle (15-20) dietary protein ATP methionine MAT S-adenosyl- methionine PPi + Pi DMG NADPH methyl acceptor MTs MTR, MTRR BHMT S-adenosyl- homocysteine Me- B12 TMG (betaine) methylated product homocysteine H2O AHCY adenosine (basic) Folate cycle (15-20) THF TS SHT MS MSR Me- B12 5,10- methylene THF 5-Methyl THF MTHFR (more complete) Folate cycle (15-20) thymidine synthesis (for DNA) dUMP THF TS serine SHT MS MSR P5P (B6) glycine Me- B12 5,10- methylene THF 5-Methyl THF MTHFR purine synthesis (for DNA/RNA) (combined) Methylation and Folate cycles (15-20) [Note that the methylation cycle and the folate cycle are present in all cells of the body (22).] thymidine synthesis (for DNA) dietary protein ATP dUMP methionine MAT THF S-adenosyl- methionine PPi + Pi DMG TS NADPH serine SHT MTs methyl acceptor MS MSR BHMT P5P (B6) S-adenosyl- homocysteine glycine Me- B12 TMG (betaine) methylated product 5,10- methylene THF 5-Methyl THF homocysteine H2O AHCY MTHFR purine synthesis (for DNA/RNA) adenosine (combined) Methylation and Folate cycles (showing link to transsulfuration pathway via CBS) (15-20) thymidine synthesis (for DNA) dietary protein ATP dUMP methionine MAT THF S-adenosyl- methionine PPi + Pi DMG TS NADPH serine SHT MTs methyl acceptor MS MSR BHMT P5P (B6) S-adenosyl- homocysteine glycine Me- B12 TMG (betaine) methylated product 5,10- methylene THF 5-Methyl THF homocysteine H2O AHCY MTHFR purine synthesis (for DNA/RNA) adenosine P5P (B6) CBS Transsulfuration pathway (15-20) [Note that a complete transsulfuration pathway is found only in cells of the liver, kidneys, pancreas, intestine, lens of the eye, and (at much lower capacity) the brain (22-24).] homocysteine serine H2O NH3 CBS P5P (B6) cystathionine alpha- ketobutyrate dietary protein P5P (B6) glycine glutamate CTH protein synthesis cysteine gamma- glutamyl- cysteine glutathione (GSH) GCL GS ATP ATP CDO Sulfoxidation and synthesis of sulfate and taurine(15-20) cysteine alpha- ketoglutarate O2 CDO CO2 cysteine- sulfinic acid GOT2 CSAD glutamate beta sulfinyl- pyruvate hypotaurine O2, H2O H+, H2O2 Mo ½ O2 spontaneous decomposition peroxynitrite

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Color:100g

doi: 10.1097/00004647-200110000-00001, 12 BadimonA.StrasburgerH