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Studies demonstrate that local heat application at 40–45°C for 20–30 minutes increases local blood flow by up to 25%, thereby decreasing prostaglandin-mediated inflammation and pain perception

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19,25,26 ), also produce hemophagocytic syndromes 27,28 , indicating that FHL3 pathology reflects impaired lytic granule exocytosis rather than disrupted late endosomal maturation 17