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4−6 Buildup of ammonia is particularly toxic to the brain where ammonia’s physiologically relevant protonated form, ammonium, can mimic K + and hinder neuronal function
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Drug Metab Dispos 2003;31:1176–86 [DOI] [PubMed] [Google Scholar] 16.Zamek-Gliszczynski MJ, Nezasa K, Tian X, Bridges AS, Lee K, Belinsky MG, Kruh GD, Brouwer KL.Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice
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