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[112] Antioxidants, including NAC, vitamin E, vitamin C, and melatonin, are currently used to treat diabetes in clinical trials [Supplementary Table 1, However, several issues need to be resolved before the successful clinical application of antioxidant strategies in those with diabetes mellitus
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In addition, HIF-1α increases the expression of iron storage proteins, including ferritin, and reduces the availability of free iron ions in the cell, thereby reducing ferroptosis (152)
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