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Therefore, this review will focus on the following aspects: (a) A basic overview of OA and ferroptosis, highlighting the pathological features of OA as well as the discovery, definition, and core regulatory mechanisms of ferroptosis

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Risk-based treatment assignment is used in children with ALL so that patients with favorable clinical and biological features who are likely to have a very good outcome with modest therapy can be spared more intensive and toxic treatment, while a more aggressive, potentially more toxic therapeutic approach is reserved for patients with a lower probability of long-term survival.[1,2] Certain ALL study groups, such as the Children’s Oncology Group (COG), use a more- or less-intensive induction regimen based on a subset of pretreatment factors, while other groups give a similar induction regimen to all patients