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Some aspects of hAAT appear to be unrelated to its ability to inhibit proteases 21,22 hAAT upregulates the expression of the anti-inflammatory cytokine 23 , IL-1 receptor antagonist (IL-1Ra) in LPS-stimulated immunocytes 17 and in the context of islet cell transplantation 24 irrespective of its ability to block elastase 21,25,26,27
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