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established cuproptosis as a critical mediator of radiotherapy-induced tumor suppression and identified its dysregulation as a key driver of radioresistance [216]
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However, one-pot enzyme immobilization within COFs is in its early stage of development, there are still some concerns about it: (i) In most cases, encapsulated enzymes have lower catalytic rates compared to their free counterparts due to the reduced mass transfer efficiency and lack of flexibility
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