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To examine if this occurred in the hypothalamus, we evaluated the morphology of astrocytes at the intersection of the median eminence and the ARC, given that these have been implicated in the entry of metabolic hormones such as leptin (Pan et al., 2008) and due to their close connection with the endothelial cells that compromise the blood–brain barrier and surrounding vascular space (Cheunsuang and Morris, 2005
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