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GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper) is a naturally occurring peptide complex that binds copper, an essential trace mineral involved in tissue repair, collagen synthesis, and antioxidant defense. It declines significantly with age, which is why
The van der Donk lab studied the biosynthesis of these compounds, including ammosamide C ( 168 ) and 3-thiaglutamate ( 169 ), using heterologous co-expression in E
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