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However, robust and reproducible anti-tumor effects were not consistently observed in vivo, likely reflecting the limited solubility and bioavailability of NPD15008, which restricted sustained systemic exposure required for long-term therapeutic evaluation
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It must also be recognized that changes in protein binding may lead the unwary to believe there is a change in clearance when in fact drug elimination is not altered (see Box: Plasma Protein Binding: Is It Important?)
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