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Biomarkers and molecular imaging A biological marker (biomarker) is defined as “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention” (194)
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Homocysteinemia was increased in all patients and brain MRI showed mostly periventricular white matter changes in 71% of cases, these patients stabilized or improved following metabolic treatment [23, 27]
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