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When compared with WT littermate F10 f/f mice, F10 f/f LysM Cre mice showed an initial tendency of increased weight gain (Figure 4D) and were not protected from DIO-induced glucose intolerance (Figure 4E)

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While expression of cytosolic TPNOX had little effect on LCL proliferation, mitochondrial TPNOX significantly diminished LCL growth (Figure 5F), indicating an important intra-mitochondrial NADPH role