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For example, augmenting CGRP signaling—such as through CGRP analogs or agonists—may promote osteogenesis and improve fracture healing, whereas inhibiting NPY signaling (e.g., via Y1 receptor antagonists) may mitigate bone loss by enhancing osteoblast activity ( 3 Interactions between bone and the gut The interactions between bone metabolism and the gut microenvironment involve highly complex and multilayered regulatory mechanisms, which are particularly evident in patients with IBD
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