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Subsequently, its distillation is described in 900 AD and its production and massive consumption were brought by the Industrial Revolution (Hogarth, There is general agreement that in high concentrations ethanol modifies some neurotransmitter receptors by allosteric binding to their hydrophobic pockets, for example on the gamma-amino butyric acid receptor (GABA-A) (Harris and Allan, Another receptor upon which ethanol generates hypnotic/anesthetic effects is the N-Methyl-D-Aspartate (NMDA) glutamate receptor (Lovinger et al., Acetaldehyde as a mediator of the effects of ethanol Crabbe et al
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