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Intranasal administration achieves the highest brain-to-plasma concentration ratios documented in any dihexa study: a 2021 pharmacokinetic analysis in Sprague-Dawley rats found that 0.5 mg/kg intranasal dihexa produced hippocampal tissue concentrations of 420 ng/g at 30 minutes post-administration, compared to 85 ng/g from 2.5 mg/kg subcutaneous injection at the same timepoint
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However, most anticancer drugs are not good substrates for GSTP1, suggesting that the contribution of GSTP1 to drug resistances might not be dependent on its capacity to detoxify chemicals or drugs
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