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It is not safe for people who have: A seizure disorder or a history of seizures (you are more likely to have a seizure if you’ve had one before or if you’re taking other medicines that increase the risk of seizures) A history of eating disorders (anorexia or bulimia) Opioid dependence or have recently used opioids Uncontrolled hypertension (high blood pressure) A history of suicidal thoughts or actions Taken monoamine oxidase inhibitors or MAOIs (antidepressants) Allergic to its ingredients If you have any of these conditions, talk to your doctor before starting Contrave, as it could increase the risk of serious side effects