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However, in a randomized phase III double-blind clinical trial, tivantinib did not improve OS time in patients with Met-high advanced HCC treated with sorafenib compared with placebo (Rimassa et al., 2018) (NCT01755767)
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As of mid-2026, neither compound is approved by the FDA or the EMA for any indication , so no established or approved human dose exists for either, and anything sold under those names outside a monitored trial is a research-use-only chemical of unverified identity
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