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Quantum chemical study of molecular properties of small branched-chain amino acids in water | Amino Acids | Springer Nature Link
We consider this superior to approaches directly targeting deficient AHCY in cases where the deficiency arises from errors of metabolism causing accumulation of metabolites that are inhibitors of AHCY 12
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Specifically, the alkyl chain in the R1 group of 46 was anchored by multiple hydrophobic interactions with G170 and surrounding side chains of residues from neighboring protomers
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