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Silverstein said he decided to investigate the over-prescribing of B12 shots, because "as an internal medicine resident, I have seen many patients come into the emergency department, and they were getting B12 injections without having a really good reason for it." His study could not determine why family physicians were prescribing it inappropriately — including whether it was initiated by the doctor or at the request of the patient
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This occurs with help from β -Arrs, which act as signaling scaffolds to a number of intracellular proteins and second messengers (Okeke et al., 2019
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