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J Clin Endocrinol Metab (2010) 95:2497–502.10.1210/jc.2009-2247 48 LuqueRMIbáñez-CostaANetoLVTaboadaGFHormaechea-AgullaDKasukiLet alTruncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas
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It is a substrate: cells need it to run the electron transport chain, generate ATP, and activate a class of repair enzymes called sirtuins and PARPs
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