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B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review
B12 digestion and absorption have five main stages: (1) release from proteins by hydrochloric acid and pepsin in the stomach [1], (2) binding to transcobalamin-I in the stomach, (3) release of B12 from transcobalamin-I by pancreatic enzymes with subsequent binding to intrinsic factor (IF) in the small intestine [16], (4) B12-IF uptake via receptor-mediated endocytosis into the enterocyte and subsequent recycling of IF in the small intestine [17], and (5) release of B12 into circulation, bound to transcobalamin-II (TC-II) [1]
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