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In conclusion, treatment with EGCG at high doses or for prolonged duration may have adverse effects, and the above data suggest that the boundary between protective and toxic doses of EGCG may be narrow
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Many CYP450 enzymes are transcriptionally regulated by the xenobiotic receptors pregnane X receptor (PXR, also known as NR1I2, SXR, or PAR) and constitutive androstane receptor (CAR
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