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The Mn-induced activation of the MAPK pathway exacerbated AD pathogenesis as Mn induced hyperphosphorylation of tau by activating the MAPK/ERK pathway in PC12 cells ( 4 Neurotherapeutics and their potential underlying mechanisms against Mn’s neurotoxicity Several pharmacological agents have been shown to exert protective effects against Mn-induced neurotoxicity by attenuating Mn-induced mitochondrial impairment, oxidative stress, inflammation, glutamate transporter dysregulation, and apoptosis in various in vitro and in vivo models
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