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For example, even with late onset initiation, in mice the non-feminizing estrogen 17α-estradiol extended median male lifespan by up to 19 percent and 90th percentile lifespan by 7%, reduced visceral adiposity, improved insulin sensitivity, lowered inflammatory markers, and suppressed mTORC1 signaling without feminization, loss of lean mass, or cardiac dysfunction (Stout et al., 2016
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