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3.2 NF-κB expression activates HAdV-C5 promoters Activation of NF-κB in response to viral pathogens is associated with the establishment of protective immunity, however the NF-κB pathway provides an attractive target to viruses as the rapid, immediate early (IE) event results in a strong transcriptional stimulation not only for cellular, but also for several early viral genes to enhance viral replication as they harbor NF-κB binding sites in their promoter sequences ( Figure 2A )