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BNF-aligned regimens are as follows: Without neurological involvement: 1 mg three times a week for two weeks, then 1 mg every three months With neurological involvement: 1 mg on alternate days until no further improvement, then 1 mg every two months Patients with neurological symptoms should be managed promptly, as delays may affect the extent of recovery

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How 5-amino-1MQ works NNMT and the SAM depletion mechanism NNMT is an enzyme that transfers a methyl group from S-adenosylmethionine (SAM) onto nicotinamide, producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)